{"id":428,"date":"2025-06-10T08:37:17","date_gmt":"2025-06-10T08:37:17","guid":{"rendered":"https:\/\/tecnomac.site\/?post_type=project&#038;p=428"},"modified":"2025-07-02T08:55:31","modified_gmt":"2025-07-02T08:55:31","slug":"articulo-development-and-validation-of-a-new-set-of-primers-for-identification-of-circulating-lineages-and-palivizumab-nirsevimab-resistance-in-hrsv-isolates-from-cabo-verde","status":"publish","type":"project","link":"https:\/\/tecnomac.site\/pt\/project\/articulo-development-and-validation-of-a-new-set-of-primers-for-identification-of-circulating-lineages-and-palivizumab-nirsevimab-resistance-in-hrsv-isolates-from-cabo-verde\/","title":{"rendered":"ARTIGO: Development and Validation of a New Set of Primers for Identification of Circulating Lineages and Palivizumab\/Nirsevimab Resistance in HRSV Isolates from Cabo Verde"},"content":{"rendered":"<p>[et_pb_section fb_built=\u00bb1&#8243; _builder_version=\u00bb4.27.2&#8243; _module_preset=\u00bbdefault\u00bb background_enable_color=\u00bboff\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_row _builder_version=\u00bb4.27.2&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4&#8243; _builder_version=\u00bb4.27.2&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_post_title _builder_version=\u00bb4.27.2&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][\/et_pb_post_title][et_pb_text _builder_version=\u00bb4.27.2&#8243; _module_preset=\u00bbdefault\u00bb hover_enabled=\u00bb0&#8243; global_colors_info=\u00bb{}\u00bb sticky_enabled=\u00bb0&#8243;]<\/p>\n<div class=\"art-authors hypothesis_container\"><span>Por: <\/span>Mar\u00eda Paula Reyes-Zuluaga, <span class=\"inlineblock \">Jos\u00e9 Antonio P\u00e9rez-P\u00e9rez, <\/span><span class=\"inlineblock \">Wilson Correia, <\/span><span class=\"inlineblock \">Isabel In\u00eas M. de Pina Ara\u00fajo y <\/span><span class=\"inlineblock \">Emma Carmelo<\/span><\/div>\n<div class=\"art-authors hypothesis_container\"><\/div>\n<div class=\"hypothesis_container\">\n<div class=\"art-affiliations\">\n<div class=\"affiliation \">\n<ul>\n<li class=\"affiliation-name \">Instituto Universitario de Enfermedades Tropicales y Salud P\u00fablica de Canarias, Universidad de La Laguna, 38200 La Laguna, Tenerife, Spain<\/li>\n<\/ul>\n<\/div>\n<div class=\"affiliation \">\n<ul>\n<li class=\"affiliation-name \">Departamento de Bioqu\u00edmica, Microbiolog\u00eda, Biolog\u00eda Celular y Gen\u00e9tica, Facultad de Ciencias, Universidad de La Laguna, 38200 La Laguna, Tenerife, Spain<\/li>\n<\/ul>\n<\/div>\n<div class=\"affiliation \">\n<ul>\n<li class=\"affiliation-name \">Faculdade de Ci\u00eancias e Tecnologia, Universidade de Cabo Verde, Praia CP 7943-010, Cape Verde<\/li>\n<\/ul>\n<\/div>\n<div class=\"affiliation \">\n<ul>\n<li class=\"affiliation-name \">oNe hEalth Research cenTer de Cabo Verde\u2014NEST-CV, Universidade de Cabo Verde, Praia CP 7943-010, Cape Verde<\/li>\n<\/ul>\n<\/div>\n<div class=\"affiliation \">\n<ul>\n<li class=\"affiliation-name \">Global Health and Tropical Medicine, GHTM, Associate Laboratory in Translation and Innovation Towards Global Health, LA-REAL, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, UNL, 1349-008 Lisboa, Portugal<\/li>\n<\/ul>\n<\/div>\n<div class=\"affiliation \">\n<ul>\n<li class=\"affiliation-name \">Departamento de Obstetricia y Ginecolog\u00eda, Pediatr\u00eda, Medicina Preventiva y Salud P\u00fablica, Toxicolog\u00eda, Medicina Legal y Forense y Parasitolog\u00eda, Universidad de La Laguna, 38200 La Laguna, Tenerife, Spain<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"bib-identity\"><em><\/em><\/div>\n<div class=\"bib-identity\"><em>Trop. Med. Infect. Dis.<\/em><span>\u00a0<\/span><b>2025<\/b>,<span>\u00a0<\/span><em>10<\/em>(6), 160;<span>\u00a0<\/span><a href=\"https:\/\/doi.org\/10.3390\/tropicalmed10060160\">https:\/\/doi.org\/10.3390\/tropicalmed10060160<\/a><\/div>\n<div class=\"bib-identity\"><\/div>\n<div class=\"bib-identity\"><\/div>\n<div class=\"bib-identity\"><strong><\/strong>\u00a0<\/div>\n<div class=\"bib-identity\"><strong>Abstract:<\/strong><\/div>\n<div class=\"bib-identity\">\n<p>En Cabo Verde, la Infecci\u00f3n Respiratoria Aguda causada por diversos pat\u00f3genos fue la afecci\u00f3n m\u00e1s notificada en ni\u00f1os menores de 5 a\u00f1os entre 2014-2020, y la cuarta causa de mortalidad en este grupo de edad, siendo el Virus Respiratorio Sincitial Humano (VRSH) uno de los principales agentes etiol\u00f3gicos. Sin embargo, la escasa literatura al respecto dificulta el estudio de su epidemiolog\u00eda y la evaluaci\u00f3n de sus potenciales implicaciones para la salud p\u00fablica. En este trabajo, desarrollamos y validamos una colecci\u00f3n de cebadores para la amplificaci\u00f3n y secuenciaci\u00f3n de los genes G y F del HRSV, utilizando un flujo de trabajo secuencial que inclu\u00eda PCR convencional y semi-anidada, seguida de secuenciaci\u00f3n Sanger. Esta estrategia no s\u00f3lo permiti\u00f3 la identificaci\u00f3n de linajes del HRSV, sino que tambi\u00e9n facilit\u00f3 la detecci\u00f3n de mutantes en la prote\u00edna F del HRSV, un paso cr\u00edtico para evaluar y asegurar la eficacia continuada de Nirsevimab o Palivizumab como terapias profil\u00e1cticas. Nuestro an\u00e1lisis revel\u00f3 la presencia de los linajes del HRSV A.D.2.2.1, A.D.3, B.D.4.1.1, y B.D.E.1, correspondientes a los linajes globalmente circulantes durante el periodo de estudio (a\u00f1os 2019 y 2022). No se encontraron mutaciones previamente descritas en la prote\u00edna F que confieran resistencia a Palivizumab y Nirsevimab. Sin embargo, la monitorizaci\u00f3n continua de los genotipos del HRSV es crucial para identificar r\u00e1pidamente los virus resistentes, teniendo en cuenta su impacto potencial en la salud p\u00fablica.<\/p>\n<p>Lea el art\u00edculo completo en <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12197772\/\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12197772\/<\/a><\/p>\n<\/div>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00bb1&#8243; _builder_version=\u00bb4.27.2&#8243; _module_preset=\u00bbdefault\u00bb background_color=\u00bb#000c26&#8243; global_module=\u00bb195&#8243; saved_tabs=\u00bball\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_row column_structure=\u00bb1_2,1_2&#8243; _builder_version=\u00bb4.27.2&#8243; _module_preset=\u00bbdefault\u00bb max_width=\u00bb2560px\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb1_2&#8243; _builder_version=\u00bb4.27.2&#8243; _module_preset=\u00bbdefault\u00bb 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Carmelo Instituto Universitario de Enfermedades Tropicales y Salud P\u00fablica de Canarias, Universidad de La Laguna, 38200 La Laguna, Tenerife, Spain Departamento de Bioqu\u00edmica, Microbiolog\u00eda, Biolog\u00eda Celular y Gen\u00e9tica, Facultad de Ciencias, Universidad de La Laguna, 38200 La Laguna, [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":350,"comment_status":"open","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"[et_pb_section fb_built=\"1\" _builder_version=\"4.27.2\" _module_preset=\"default\" background_enable_color=\"off\" global_colors_info=\"{}\"][et_pb_row _builder_version=\"4.27.2\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.27.2\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_post_title _builder_version=\"4.27.2\" _module_preset=\"default\" global_colors_info=\"{}\"][\/et_pb_post_title][et_pb_gallery _builder_version=\"4.27.2\" 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