{"id":428,"date":"2025-06-10T08:37:17","date_gmt":"2025-06-10T08:37:17","guid":{"rendered":"https:\/\/tecnomac.site\/?post_type=project&#038;p=428"},"modified":"2025-07-02T08:55:31","modified_gmt":"2025-07-02T08:55:31","slug":"articulo-development-and-validation-of-a-new-set-of-primers-for-identification-of-circulating-lineages-and-palivizumab-nirsevimab-resistance-in-hrsv-isolates-from-cabo-verde","status":"publish","type":"project","link":"https:\/\/tecnomac.site\/pt\/project\/articulo-development-and-validation-of-a-new-set-of-primers-for-identification-of-circulating-lineages-and-palivizumab-nirsevimab-resistance-in-hrsv-isolates-from-cabo-verde\/","title":{"rendered":"ARTIGO: Development and Validation of a New Set of Primers for Identification of Circulating Lineages and Palivizumab\/Nirsevimab Resistance in HRSV Isolates from Cabo Verde"},"content":{"rendered":"<p>[et_pb_section fb_built=\u00bb1&#8243; _builder_version=\u00bb4.27.2&#8243; _module_preset=\u00bbdefault\u00bb background_enable_color=\u00bboff\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_row _builder_version=\u00bb4.27.2&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4&#8243; _builder_version=\u00bb4.27.2&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_post_title _builder_version=\u00bb4.27.2&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][\/et_pb_post_title][et_pb_text _builder_version=\u00bb4.27.2&#8243; _module_preset=\u00bbdefault\u00bb hover_enabled=\u00bb0&#8243; global_colors_info=\u00bb{}\u00bb sticky_enabled=\u00bb0&#8243;]<\/p>\n<div class=\"art-authors hypothesis_container\"><span>Por: <\/span>Mar\u00eda Paula Reyes-Zuluaga, <span class=\"inlineblock\">Jos\u00e9 Antonio P\u00e9rez-P\u00e9rez, <\/span><span class=\"inlineblock\">Wilson Correia, <\/span><span class=\"inlineblock\">Isabel In\u00eas M. de Pina Ara\u00fajo y <\/span><span class=\"inlineblock\">Emma Carmelo<\/span><\/div>\n<div class=\"art-authors hypothesis_container\"><\/div>\n<div class=\"hypothesis_container\">\n<div class=\"art-affiliations\">\n<div class=\"affiliation\">\n<ul>\n<li class=\"affiliation-name\">Instituto Universitario de Enfermedades Tropicales y Salud P\u00fablica de Canarias, Universidad de La Laguna, 38200 La Laguna, Tenerife, Spain<\/li>\n<\/ul>\n<\/div>\n<div class=\"affiliation\">\n<ul>\n<li class=\"affiliation-name\">Departamento de Bioqu\u00edmica, Microbiolog\u00eda, Biolog\u00eda Celular y Gen\u00e9tica, Facultad de Ciencias, Universidad de La Laguna, 38200 La Laguna, Tenerife, Spain<\/li>\n<\/ul>\n<\/div>\n<div class=\"affiliation\">\n<ul>\n<li class=\"affiliation-name\">Faculdade de Ci\u00eancias e Tecnologia, Universidade de Cabo Verde, Praia CP 7943-010, Cape Verde<\/li>\n<\/ul>\n<\/div>\n<div class=\"affiliation\">\n<ul>\n<li class=\"affiliation-name\">oNe hEalth Research cenTer de Cabo Verde\u2014NEST-CV, Universidade de Cabo Verde, Praia CP 7943-010, Cape Verde<\/li>\n<\/ul>\n<\/div>\n<div class=\"affiliation\">\n<ul>\n<li class=\"affiliation-name\">Global Health and Tropical Medicine, GHTM, Associate Laboratory in Translation and Innovation Towards Global Health, LA-REAL, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, UNL, 1349-008 Lisboa, Portugal<\/li>\n<\/ul>\n<\/div>\n<div class=\"affiliation\">\n<ul>\n<li class=\"affiliation-name\">Departamento de Obstetricia y Ginecolog\u00eda, Pediatr\u00eda, Medicina Preventiva y Salud P\u00fablica, Toxicolog\u00eda, Medicina Legal y Forense y Parasitolog\u00eda, Universidad de La Laguna, 38200 La Laguna, Tenerife, Spain<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"bib-identity\"><em><\/em><\/div>\n<div class=\"bib-identity\"><em>Trop. Med. Infect. Dis.<\/em><span>\u00a0<\/span><b>2025<\/b>,<span>\u00a0<\/span><em>10<\/em>(6), 160;<span>\u00a0<\/span><a href=\"https:\/\/doi.org\/10.3390\/tropicalmed10060160\">https:\/\/doi.org\/10.3390\/tropicalmed10060160<\/a><\/div>\n<div class=\"bib-identity\"><\/div>\n<div class=\"bib-identity\"><\/div>\n<div class=\"bib-identity\"><strong><\/strong>\u00a0<\/div>\n<div class=\"bib-identity\"><strong>Abstract:<\/strong><\/div>\n<div class=\"bib-identity\">\n<p>Em Cabo Verde, a Infe\u00e7\u00e3o Respirat\u00f3ria Aguda causada por v\u00e1rios agentes patog\u00e9nicos foi a patologia mais notificada em crian\u00e7as menores de 5 anos entre 2014-2020, e a quarta causa de mortalidade neste grupo et\u00e1rio, sendo o V\u00edrus Sincicial Respirat\u00f3rio Humano (VSR) um dos principais agentes etiol\u00f3gicos. No entanto, a escassa literatura sobre o tema dificulta o estudo da sua epidemiologia e a avalia\u00e7\u00e3o das suas potenciais implica\u00e7\u00f5es na sa\u00fade p\u00fablica. Neste trabalho, desenvolvemos e valid\u00e1mos uma cole\u00e7\u00e3o de primers para a amplifica\u00e7\u00e3o e sequencia\u00e7\u00e3o dos genes G e F do HRSV, utilizando um fluxo de trabalho sequencial que incluiu PCR convencional e semi-nested seguido de sequencia\u00e7\u00e3o Sanger. Esta estrat\u00e9gia n\u00e3o s\u00f3 permitiu a identifica\u00e7\u00e3o de linhagens de HRSV, como tamb\u00e9m facilitou a dete\u00e7\u00e3o de mutantes da prote\u00edna F do HRSV, um passo fundamental para avaliar e garantir a efic\u00e1cia cont\u00ednua do Nirsevimab ou do Palivizumab como terapias profil\u00e1cticas. A nossa an\u00e1lise revelou a presen\u00e7a das linhagens de HRSV A.D.2.2.1, A.D.3, B.D.4.1.1 e B.D.E.1, correspondendo \u00e0s linhagens que circularam globalmente durante o per\u00edodo do estudo (anos de 2019 e 2022). N\u00e3o foram encontradas muta\u00e7\u00f5es previamente descritas na prote\u00edna F que conferissem resist\u00eancia ao Palivizumab e ao Nirsevimab. No entanto, a monitoriza\u00e7\u00e3o cont\u00ednua dos gen\u00f3tipos do HRSV \u00e9 crucial para identificar rapidamente os v\u00edrus resistentes, dado o seu potencial impacto na sa\u00fade.<\/p>\n<p>Ler o artigo completo em <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12197772\/\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12197772\/<\/a><\/p>\n<\/div>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00bb1&#8243; _builder_version=\u00bb4.27.2&#8243; _module_preset=\u00bbdefault\u00bb background_color=\u00bb#000c26&#8243; global_module=\u00bb195&#8243; saved_tabs=\u00bball\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_row column_structure=\u00bb1_2,1_2&#8243; _builder_version=\u00bb4.27.2&#8243; _module_preset=\u00bbdefault\u00bb max_width=\u00bb2560px\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb1_2&#8243; _builder_version=\u00bb4.27.2&#8243; _module_preset=\u00bbdefault\u00bb 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y Emma Carmelo Instituto Universitario de Enfermedades Tropicales y Salud P\u00fablica de Canarias, Universidad de La Laguna, 38200 La Laguna, Tenerife, Spain Departamento de Bioqu\u00edmica, Microbiolog\u00eda, Biolog\u00eda Celular y Gen\u00e9tica, Facultad de Ciencias, Universidad de La Laguna, 38200 La Laguna, [&hellip;]<\/p>","protected":false},"author":2,"featured_media":350,"comment_status":"open","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"[et_pb_section fb_built=\"1\" _builder_version=\"4.27.2\" _module_preset=\"default\" background_enable_color=\"off\" global_colors_info=\"{}\"][et_pb_row _builder_version=\"4.27.2\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.27.2\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_post_title _builder_version=\"4.27.2\" _module_preset=\"default\" global_colors_info=\"{}\"][\/et_pb_post_title][et_pb_gallery 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